VoxHRNet - Whole Brain Segmentation with Full Volume Neural Network

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Deep LearningVoxHRNet
Overview

VoxHRNet

This is the official implementation of the following paper:

Whole Brain Segmentation with Full Volume Neural Network

Yeshu Li, Jonathan Cui, Yilun Sheng, Xiao Liang, Jingdong Wang, Eric I-Chao Chang, Yan Xu

Computerized Medical Imaging and Graphics

[arXiv]

Network

architecture

Installation

The following environments/libraries are required:

  • Python 3
  • yacs
  • SimpleITK
  • apex
  • pytorch
  • nibabel
  • numpy
  • scikit-image
  • scipy

Quick Start

Data Preparation

Download the LPBA40 and Hammers n30r95 datasets.

After renaming, your directory tree should look like:

$ROOT
├── data
│   └── LPBA40_N4_RN
│       ├── aseg_TEST001.nii.gz
│       ├── ...
│       ├── aseg_TEST010.nii.gz
│       ├── aseg_TRAIN001.nii.gz
│       ├── ...
│       ├── aseg_TRAIN027.nii.gz
│       ├── aseg_VALIDATE001.nii.gz
│       ├── ...
│       ├── aseg_VALIDATE003.nii.gz
│       ├── orig_TEST001.nii.gz
│       ├── ...
│       ├── orig_TEST010.nii.gz
│       ├── orig_TRAIN001.nii.gz
│       ├── ...
│       ├── orig_TRAIN027.nii.gz
│       ├── orig_VALIDATE001.nii.gz
│       ├── ...
│       └── orig_VALIDATE003.nii.gz
└── VoxHRNet
    ├── voxhrnet.py
    ├── ...
    └── train.py

Create a YACS configuration file and make changes for specific training/test settings accordingly. We use config_lpba.yaml as an example as follows.

Train

Run

python3 train.py --cfg config_lpba.yaml

Test

Run

python3 test.py --cfg config_lpba.yaml

Pretrained Models

For the LPBA40 dataset, we number the subjects from 1-40 alphabetically and split them into 4 folds sequentially. The k-th fold is selected as the test set in the k-th split.

For the Hammers n30r95 dataset, the first 20 subjects and last 10 subjects are chosen as the training and test set respectively.

Their pretrained models can be found in the release page of this repository.

Citation

Please cite our work if you find it useful in your research:

@article{LI2021101991,
title = {Whole brain segmentation with full volume neural network},
journal = {Computerized Medical Imaging and Graphics},
volume = {93},
pages = {101991},
year = {2021},
issn = {0895-6111},
doi = {https://doi.org/10.1016/j.compmedimag.2021.101991},
url = {https://www.sciencedirect.com/science/article/pii/S0895611121001403},
author = {Yeshu Li and Jonathan Cui and Yilun Sheng and Xiao Liang and Jingdong Wang and Eric I.-Chao Chang and Yan Xu},
keywords = {Brain, Segmentation, Neural networks, Deep learning},
abstract = {Whole brain segmentation is an important neuroimaging task that segments the whole brain volume into anatomically labeled regions-of-interest. Convolutional neural networks have demonstrated good performance in this task. Existing solutions, usually segment the brain image by classifying the voxels, or labeling the slices or the sub-volumes separately. Their representation learning is based on parts of the whole volume whereas their labeling result is produced by aggregation of partial segmentation. Learning and inference with incomplete information could lead to sub-optimal final segmentation result. To address these issues, we propose to adopt a full volume framework, which feeds the full volume brain image into the segmentation network and directly outputs the segmentation result for the whole brain volume. The framework makes use of complete information in each volume and can be implemented easily. An effective instance in this framework is given subsequently. We adopt the 3D high-resolution network (HRNet) for learning spatially fine-grained representations and the mixed precision training scheme for memory-efficient training. Extensive experiment results on a publicly available 3D MRI brain dataset show that our proposed model advances the state-of-the-art methods in terms of segmentation performance.}
}

Acknowledgement

A large part of the code is borrowed from HRNet.

Contributing

This project welcomes contributions and suggestions. Most contributions require you to agree to a Contributor License Agreement (CLA) declaring that you have the right to, and actually do, grant us the rights to use your contribution. For details, visit https://cla.opensource.microsoft.com.

When you submit a pull request, a CLA bot will automatically determine whether you need to provide a CLA and decorate the PR appropriately (e.g., status check, comment). Simply follow the instructions provided by the bot. You will only need to do this once across all repos using our CLA.

This project has adopted the Microsoft Open Source Code of Conduct. For more information see the Code of Conduct FAQ or contact [email protected] with any additional questions or comments.

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Comments
  • How to get the LPBA40_N4_RN dataset for the example

    How to get the LPBA40_N4_RN dataset for the example

    Thanks for your great work. I'm trying to run the example but stuck by the dataset. It seems there are multiple LPBA40 datasets on the give site LPBA40, and the data file format are not nii as in the example. Is there a downloadable LPBA40_N4_RN dataset or could you give some details on how to generate the dataset in the example?

    opened by mgcyung 2
  • ACTION REQUIRED: Microsoft needs this private repository to complete compliance info

    ACTION REQUIRED: Microsoft needs this private repository to complete compliance info

    There are open compliance tasks that need to be reviewed for your VoxHRNet repo.

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    Please take a few minutes to complete the tasks at: https://repos.opensource.microsoft.com/orgs/microsoft/repos/VoxHRNet/compliance

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